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・ Phosphatidylinositol 4-phosphate
・ Phosphatidylinositol 5-phosphate
・ Phosphatidylinositol a-mannosyltransferase
・ Phosphatidylinositol bisphosphate
・ Phosphatidylinositol deacylase
・ Phosphatidylinositol diacylglycerol-lyase
・ Phosphatidylinositol N-acetylglucosaminyltransferase
・ Phosphatidylinositol phosphate
・ Phosphatidylinositol phosphate kinases
・ Phosphatidylinositol transfer protein
・ Phosphatidylinositol transfer protein, alpha
・ Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
・ Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
・ Phosphatidylinositol-3,4-bisphosphate 4-phosphatase
・ Phosphatidylinositol-3-phosphatase
Phosphatidylinositol-4,5-bisphosphate 3-kinase
・ Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
・ Phosphatidylinositol-4-phosphate 3-kinase
・ Phosphatidylmyo-inositol mannosides
・ Phosphatidylserine
・ Phosphatidylserine decarboxylase
・ Phosphatocopida
・ Phosphatodraco
・ Phosphatosaurus
・ Phosphatrioxa-adamantane
・ Phosphaturic mesenchymal tumor
・ Phosphazene
・ Phosphene
・ Phosphene Dream
・ Phosphichthys


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Phosphatidylinositol-4,5-bisphosphate 3-kinase : ウィキペディア英語版
Phosphatidylinositol-4,5-bisphosphate 3-kinase

In enzymology, a phosphatidylinositol-4,5-bisphosphate 3-kinase () is an enzyme that catalyzes the chemical reaction
:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate \rightleftharpoons ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase. This enzyme is also called type I phosphoinositide 3-kinase. This enzyme participates in 29 metabolic pathways: inositol phosphate metabolism, erbb signaling pathway, phosphatidylinositol signaling system, mtor signaling pathway, apoptosis, VEGF signaling pathway, focal adhesion, toll-like receptor signaling pathway, jak-stat signaling pathway, natural killer cell mediated cytotoxicity, t cell receptor signaling pathway, b cell receptor signaling pathway, fc epsilon ri signaling pathway, leukocyte transendothelial migration, regulation of actin cytoskeleton, insulin signaling pathway, progesterone-mediated oocyte maturation, Type II diabetes mellitus, colorectal cancer, renal cell carcinoma, pancreatic cancer, endometrial cancer, glioma, prostate cancer, melanoma, chronic myeloid leukemia, acute myeloid leukemia, small cell lung cancer, and non-small cell lung cancer.
==Structural studies==

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .

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